abstract：:Protein tyrosine phosphorylation is a key regulatory process in virtually all aspects of cellular functions. Dysregulation of protein tyrosine phosphorylation is a major cause of human diseases, such as cancers, diabetes, autoimmune disorders, and neurological diseases. Indeed, protein tyrosine phosphorylation-mediate...

journal_title：Acta pharmacologica Sinica

authors： He RJ,Yu ZH,Zhang RY,Zhang ZY

更新日期：2014-10-01 00:00:00

abstract：AIM:The non-neuronal acetylcholine system (NNAS) in endothelial cells participates in modulating endothelial function, vascular tone, angiogenesis and inflammation, thus plays a critical role in cardiovascular diseases. In this study, we used a proteomic approach to study potential downstream receptor-effectors of NNAS...

journal_title：Acta pharmacologica Sinica

authors： Zhang YY,Shen W,Zhang LC,Pan ZY,Long CL,Cui WY,Zhang YF,Wang H

更新日期：2014-09-01 00:00:00

abstract：AIM:Abrus agglutinin (AGG) from the seeds of Indian medicinal plant Abrus precatorius belongs to the class II ribosome inactivating protein family. In this study we investigated the anticancer effects of AGG against human hepatocellular carcinoma in vitro and in vivo. METHODS:Cell proliferation, DNA fragmentation, Ann...

journal_title：Acta pharmacologica Sinica

authors： Mukhopadhyay S,Panda PK,Das DN,Sinha N,Behera B,Maiti TK,Bhutia SK

更新日期：2014-06-01 00:00:00

abstract：AIM:To evaluation the doxorubicin (DOX)-loaded pH-sensitive polymeric micelle release from tumor blood vessels into tumor interstitium using an animal vessel visibility model, the so-called dorsal skin-fold window chamber model. METHODS:DOX-loaded pH-sensitive polyHis-b-PEG micelles and DOX-loaded pH-insensitive PLLA-...

journal_title：Acta pharmacologica Sinica

authors： Jin ZH,Jin MJ,Jiang CG,Yin XZ,Jin SX,Quan XQ,Gao ZG

更新日期：2014-06-01 00:00:00

abstract：AIM:Human umbilical cord blood mesenchymal stem cells (hUCB-MSCs) have been shown to ameliorate cerebral ischemia in animal models. In this study we investigated the effects of hUCB-MSCs on inflammatory responses and neuronal apoptosis during the early stage of focal cerebral ischemia in rabbits. METHODS:Focal cerebra...

journal_title：Acta pharmacologica Sinica

authors： Zhu Y,Guan YM,Huang HL,Wang QS

更新日期：2014-05-01 00:00:00

abstract：AIM:To investigate the effects of co-delivering IL-6 expressing plasmid pCI-IL-6 on the immunogenicity of the anti-caries DNA vaccine pCIA-P, which encodes the surface protein antigen PAc of Streptococcus mutans. METHODS:Plasmid pCI-IL-6 was constructed by inserting the murine IL-6 gene into the pCI vector. Expression...

journal_title：Acta pharmacologica Sinica

authors： Su LK,Yu F,Li ZF,Zeng C,Xu QA,Fan MW

更新日期：2014-05-01 00:00:00

abstract：:Lactoferrin (Lf) is an iron-binding glycoprotein of the transferrin family, which is expressed in most biological fluids with particularly high levels in mammalian milk. Its multiple activities lie in its capacity to bind iron and to interact with the molecular and cellular components of hosts and pathogens. Lf can bi...

journal_title：Acta pharmacologica Sinica

authors： Siqueiros-Cendón T,Arévalo-Gallegos S,Iglesias-Figueroa BF,García-Montoya IA,Salazar-Martínez J,Rascón-Cruz Q

更新日期：2014-05-01 00:00:00

abstract：:Neuronal nicotinic acetylcholine receptors are important targets for alcohol reward and dependence. Alcoholism is a serious public health problem and has been identified as the third major cause of preventable mortality in the world. Worldwide, about 2 billion people consume alcohol, with 76.3 million having diagnosab...

journal_title：Acta pharmacologica Sinica

authors： Wu J,Gao M,Taylor DH

更新日期：2014-03-01 00:00:00

abstract：AIM:To examine the therapeutic effects and underlying mechanisms of DZ2002, a reversible S-adenosyl-L-homocysteine hydrolase (SAHH) inhibitor, on lupus-prone female NZB×NZW F1 (NZB/W F1) mice. METHODS:Female NZB/W F1 mice were treated orally with DZ2002 (0.5 mg·kg(-1)·d(-1)) for 11 weeks, and the proteinuria level and...

journal_title：Acta pharmacologica Sinica

authors： He SJ,Lin ZM,Wu YW,Bai BX,Yang XQ,He PL,Zhu FH,Tang W,Zuo JP

更新日期：2014-02-01 00:00:00

abstract：AIM:Tolsultazolamide, a novel carbonic anhydrase inhibitor, is designed for the prophylaxis and treatment of acute mountain sickness. The aim of this study was to investigate the pharmacokinetics, tissue distribution, and excretion characteristics of tolsultazolamide and the sex difference in pharmacokinetics in rats. ...

journal_title：Acta pharmacologica Sinica

authors： Wang JD,Shi YP,Yin J,Pan ZY,Cui WY,Zhang YF,Wang H

更新日期：2014-02-01 00:00:00

abstract：AIM:To investigate the effects of phorbol 12-myristate 13-acetate (PMA), a PKC activator, on P-glycoprotein-mediated efflux of digoxin in two cell transport models. METHODS:Caco-2 cells, wild MDCKII cells (MDCKII-WT) and MDCKII cells transfected stably with human MDR1-gene encoding P-gp (MDCKII-MDR1) were examined. Ce...

journal_title：Acta pharmacologica Sinica

authors： Li YH,Bi HC,Huang L,Jin J,Zhong GP,Zhou XN,Huang M

更新日期：2014-02-01 00:00:00

abstract：AIM:To investigate the effects of diosgenin (Dio), a naturally occurring steroid saponin, on goiter formation in a mouse model of Graves' disease (GD) and the underlying mechanisms. METHODS:Female BALB/c mice were injected with adenovirus expressing the A subunit of thyrotropin receptor to induce GD. The mice were tre...

journal_title：Acta pharmacologica Sinica

authors： Cai H,Wang Z,Zhang HQ,Wang FR,Yu CX,Zhang FX,Gao L,Zhang J,Zhao JJ

更新日期：2014-01-01 00:00:00

abstract：AIM:To investigate the protective effects of hydrogen sulfide (H2S) against inflammation, oxidative stress and apoptosis in a rat model of resuscitated hemorrhagic shock. METHODS:Hemorrhagic shock was induced in adult male SD rats by drawing blood from the femoral artery for 10 min. The mean arterial pressure was main...

journal_title：Acta pharmacologica Sinica

authors： Xu DQ,Gao C,Niu W,Li Y,Wang YX,Gao CJ,Ding Q,Yao LN,Chai W,Li ZC

更新日期：2013-12-01 00:00:00

abstract：AIM:Both endothelin ETA receptor antagonists and angiotensin AT1 receptor antagonists lower blood pressure in hypertensive patients. A dual AT1 and ETA receptor antagonist may be more efficacious antihypertensive drug. In this study we identified the mode and mechanism of binding of imidazole series of compounds as dua...

journal_title：Acta pharmacologica Sinica

authors： Singh KD,Muthusamy K

更新日期：2013-12-01 00:00:00

abstract：AIM:To examine the effects of β3-adrenoceptor (β3-AR) activation on atherosclerotic plaque development in ApoE(-/-) mice. METHODS:Thirty six week-old male ApoE(-/-) mice on a high-fat diet were treated with atorvastatin (10 mg·kg(-1)·d(-1), po), BRL37344 (β3-AR agonist, 1.65 or 3.30 μg/kg, ip, twice a week) or SR52390...

journal_title：Acta pharmacologica Sinica

authors： Wang ZH,Li YF,Guo YQ

更新日期：2013-09-01 00:00:00

abstract：AIM:Breviscapine isolated from the Chinese herb Erigeron breviscapus (Vant) Hand-Mazz is widely used to treat cardiovascular and cerebrovascular diseases. The aim of this study was to improve the pharmacokinetic profiles of breviscapine using nanostructured lipid carrier based on an ionic complex formation. METHODS:Br...

journal_title：Acta pharmacologica Sinica

authors： Li M,Zheng Y,Shan FY,Zhou J,Gong T,Zhang ZR

更新日期：2013-08-01 00:00:00

abstract：AIM:The conventional method for analyzing 24-h ambulatory blood pressure monitoring (24-h ABPM) is insufficient to deal with the large amount of data collected. The aim of this study was to develop a novel cyclic fluctuation model for 24-h ABPM in Chinese patients with mild to moderate hypertension. METHODS:The data w...

journal_title：Acta pharmacologica Sinica

authors： Sheng YC,Wang K,Xu L,Yang J,He YC,Zheng QS

更新日期：2013-08-01 00:00:00

abstract：AIM:To investigate the actions of the muscarinic agonist carbachol on glutamate-induced neurotoxicity in PC12 cells, and the underlying mechanisms. METHODS:PC12 cells were treated with different concentrations of glutamate for 24 or 48 h. The cell viability was measured using MTT assay, and the expression and activati...

journal_title：Acta pharmacologica Sinica

authors： Ma K,Yang LM,Chen HZ,Lu Y

更新日期：2013-07-01 00:00:00

abstract：AIM:To investigate the effects and underlying mechanisms of 118, a novel derivative of mycophenolic acid, in a murine allogeneic skin graft model. METHODS:Skin grafts were conducted by grafting BALB/c donor tail skin into C57BL/6 skin beds (allograft) or by grafting female C57BL/6 donor tail skin into female C57BL/6 s...

journal_title：Acta pharmacologica Sinica

authors： Kong FY,Chen W,He SJ,Lin ZM,Li X,Zhang XH,Yang XQ,Zhu FH,Tong XK,Zhou Y,Tang W,Duan WH,Zuo JP

更新日期：2013-07-01 00:00:00

abstract：:The revolutionary induced pluripotent stem cell (iPSC) technology provides a new path for cell replacement therapies and drug screening. Patient-specific iPSCs and subsequent differentiated cells manifesting disease phenotypes will finally position human disease pathology at the core of drug discovery. Cells used to t...

journal_title：Acta pharmacologica Sinica

authors： Zhang R,Zhang LH,Xie X

更新日期：2013-06-01 00:00:00

abstract：AIM:High mobility group box protein 1 (HMGB1) and receptor for the advanced glycation end product (RAGE) play pivotal roles in vascular inflammation and atherosclerosis. The aim of this study was to determine whether the HMGB1-RAGE axis was involved in the actions of simvastatin on vascular inflammation and atheroscler...

journal_title：Acta pharmacologica Sinica

authors： Liu M,Yu Y,Jiang H,Zhang L,Zhang PP,Yu P,Jia JG,Chen RZ,Zou YZ,Ge JB

更新日期：2013-06-01 00:00:00

abstract：:As autophagy is involved in cell growth, survival, development and death, impaired autophagic flux has been linked to a variety of human pathophysiological processes, including neurodegeneration, cancer, myopathy, cardiovascular and immune-mediated disorders. There is a growing need to identify and quantify the status...

journal_title：Acta pharmacologica Sinica

authors： Zhang XJ,Chen S,Huang KX,Le WD

更新日期：2013-05-01 00:00:00

abstract：:Autophagy is a cell self-digestion process via lysosomes that clears "cellular waste", including aberrantly modified proteins or protein aggregates and damaged organelles. Therefore, autophagy is considered a protein and organelle quality control mechanism that maintains normal cellular homeostasis. Dysfunctional auto...

journal_title：Acta pharmacologica Sinica

authors： He LQ,Lu JH,Yue ZY

更新日期：2013-05-01 00:00:00

abstract：AIM:To investigate the effects of salvianolate, a water-soluble active compound from Salvia miltiorrhiza Bunge, on reactive oxygen species (ROS) production in mouse cardiomyocytes in vitro. METHODS:Primary ventricular cardiomyocytes were prepared from neonatal mouse. The cell viability was determined using MTT assay. ...

journal_title：Acta pharmacologica Sinica

authors： Fei AH,Cao Q,Chen SY,Wang HR,Wang FL,Pan SM,Lin ZF

更新日期：2013-04-01 00:00:00

abstract：AIM:To investigate the influences of betulinic acid (BA), a triterpenoid isolated from birch bark, on neuroinflammatory mediators involved in the pathogenesis of multiple sclerosis and experimental autoimmune encephalomyelitis in vitro. METHODS:Encephalitogenic T cells were prepared from draining lymph nodes and spina...

journal_title：Acta pharmacologica Sinica

authors： Blaževski J,Petković F,Momčilović M,Paschke R,Kaluđerović GN,Mostarica Stojković M,Miljković D

更新日期：2013-03-01 00:00:00

abstract：AIM:Benzothiophene compounds are selective estrogen receptor modulators (SERMs), which are recently found to activate antioxidant signaling. In this study the molecular mechanisms of antioxidant signaling activation by benzothiophene compound BC-1 were investigated. METHODS:HepG2 cells were stably transfected with ant...

journal_title：Acta pharmacologica Sinica

authors： Yu BL,Mai ZX,Liu XX,Huang ZF

更新日期：2013-03-01 00:00:00

abstract：:The combination of technological advances, genomic sequences and market success is catalyzing rapid development of antibody-based therapeutics. Cell surface receptors and ion channel proteins are well known drug targets, but the latter has seen less success. The availability of crystal structures, better understanding...

journal_title：Acta pharmacologica Sinica

authors： Sun H,Li M

更新日期：2013-02-01 00:00:00

abstract：AIM:To examine the anti-cancer effects of chamaejasmenin B and neochamaejasmin C, two biflavonones isolated from the root of Stellera chamaejasme L (known as the traditional Chinese herb Rui Xiang Lang Du) in vitro. METHODS:Human liver carcinoma cell lines (HepG2 and SMMC-7721), a human non-small cell lung cancer cell...

journal_title：Acta pharmacologica Sinica

authors： Zhang C,Zhou SS,Feng LY,Zhang DY,Lin NM,Zhang LH,Pan JP,Wang JB,Li J

更新日期：2013-02-01 00:00:00

abstract：AIM:To investigate the antitumor actions of the Crotalus durissus neurotoxin (crotoxin) on human esophageal carcinoma (Eca-109) cells in vitro and transplanted esophageal Eca-109 tumors in nude mice. METHODS:The growth-inhibitory effect was analyzed in Eca-109 cells using MTT assay. Cell morphology changes in nuclei w...

journal_title：Acta pharmacologica Sinica

authors： He JK,Wu XS,Wang Y,Han R,Qin ZH,Xie Y

更新日期：2013-02-01 00:00:00

abstract：AIM:Gemcitabine has been increasingly prescribed for the treatment of gallbladder cancer. However, the response rate is low. The aim of this study is to determine whether icariin, a flavonoid isolated from Epimedi herba, could potentiate the antitumor activity of gemcitabine in gallbladder cancer. METHODS:Human gallbl...

journal_title：Acta pharmacologica Sinica

authors： Zhang DC,Liu JL,Ding YB,Xia JG,Chen GY

更新日期：2013-02-01 00:00:00

abstract：AIM:To examine how the higher expression level of CYP3A4 isoenzyme influenced the cytotoxicity of the antitumor triazoloacridinone derivative C-1305 in Chinese hamster ovary (CHO) cells. METHODS:Three CHO cell lines were examined: wild-type CHO cells; CHO-HR cells with overexpression of human cytochrome P450 reductase...

journal_title：Acta pharmacologica Sinica

authors： Augustin E,Borowa-Mazgaj B,Kikulska A,Kordalewska M,Pawłowska M

更新日期：2013-01-01 00:00:00

abstract：AIM:To determine the postshock activation patterns with both successful and failed shocks in a canine model of ventricular fibrillation, and whether piniacidil, an early after-depolarization (EAD) inhibitor, altered the defibrillation threshold (DFT) and postshock activation patterns. METHODS:In 6 beagles, a basket ca...

journal_title：Acta pharmacologica Sinica

authors： Jin Q,Zhang N,Zhou J,Lin CJ,Pang Y,Gu G,Shen WF,Wu LQ

更新日期：2012-12-01 00:00:00

abstract：AIM:To evaluate retrospectively the association of cytochrome P450 3A (CYP3A) and ATP-binding cassette sub-family B member 1 (ABCB1) gene polymorphisms with the pharmacokinetics of cyclosporine A (CsA) in Chinese renal transplant patients. METHODS:One hundred and twenty-six renal transplant patients were recruited. Bl...

journal_title：Acta pharmacologica Sinica

authors： Meng XG,Guo CX,Feng GQ,Zhao YC,Zhou BT,Han JL,Chen X,Shi Y,Shi HY,Yin JY,Peng XD,Pei Q,Zhang W,Wang G,He M,Liu M,Yang JK,Zhou HH

更新日期：2012-12-01 00:00:00

abstract：AIM:To identify a small molecule L655,240 as a novel β-secretase (BACE1) inhibitor and to investigate its effects on β-amyloid (Aβ) generation in vitro. METHODS:Fluorescence resonance energy transfer (FRET) was used to characterize the inhibitory effect of L655,240 on BACE1. Surface plasmon resonance (SPR) technology-...

journal_title：Acta pharmacologica Sinica

authors： Lu Q,Chen WY,Zhu ZY,Chen J,Xu YC,Kaewpet M,Rukachaisirikul V,Chen LL,Shen X

更新日期：2012-12-01 00:00:00

abstract：AIM:To establish a population pharmacokinetics (PPK) model for lamotrigine (LTG) in Chinese children with epilepsy in order to formulate an individualized dosage guideline. METHODS:LTG steady-state plasma concentration data from therapeutic drug monitoring (TDM) were collected retrospectively from 284 patients, with a...

journal_title：Acta pharmacologica Sinica

authors： He DK,Wang L,Qin J,Zhang S,Lu W,Li L,Zhang JM,Bao WQ,Song XQ,Liu HT

更新日期：2012-11-01 00:00:00

abstract：AIM:To develop a combined population pharmacokinetic model (PPK) to assess the magnitude and variability of exposure to both clozapine and its primary metabolite norclozapine in Chinese patients with refractory schizophrenia via sparse sampling with a focus on the effects of covariates on the pharmacokinetic parameters...

journal_title：Acta pharmacologica Sinica

authors： Li LJ,Shang DW,Li WB,Guo W,Wang XP,Ren YP,Li AN,Fu PX,Ji SM,Lu W,Wang CY

更新日期：2012-11-01 00:00:00

abstract：AIM:To investigate the prevalence of hepatitis B virus (HBV) genotype mixtures among patients with chronic hepatitis B (CHB) in Eastern China. METHODS:A total of 4908 chronic HBV patients from Eastern China were enrolled. HBV genotypes and subgenotypes were determined using a multiplex PCR technique. Serum viral loads...

journal_title：Acta pharmacologica Sinica

authors： Zhong J,Gao YQ,Sun XH,Zhu XJ,Li M

更新日期：2012-10-01 00:00:00

abstract：AIM:Recent studies have shown that constitutive activation of the nuclear factor κB (NF-κB) plays a key role in chronic inflammation and cancers. The aim of this study was to characterize lobolide, a cembrane diterpene, as a drug candidate targeting the NF-κB signaling pathway. METHODS:A HEK 293/NF-κB-Luc stable cell ...

journal_title：Acta pharmacologica Sinica

authors： Lv XF,Chen SH,Li J,Fang JP,Guo YW,Ding K

更新日期：2012-10-01 00:00:00

abstract：AIM:Filamin binding LIM protein 1, also known as migfilin, is a skeleton organization protein that binds to mitogen-inducible gene 2 at cell-extracellular matrix adhesions. The aim of this study was to investigate the role of migfilin in cisplatin-induced apoptosis in human glioma cells, to determine the functional dom...

journal_title：Acta pharmacologica Sinica

authors： Fan J,Ou YW,Wu CY,Yu CJ,Song YM,Zhan QM

更新日期：2012-10-01 00:00:00

abstract：AIM:Fibroblast growth factor 7 (FGF7) is involved in a number of physiological and pathological processes, including lung disease. However, relatively little is known about the effect of FGF7 gene polymorphisms on chronic obstructive pulmonary disease (COPD) susceptibility. This study aimed to investigate the associati...

journal_title：Acta pharmacologica Sinica

authors： Xu SC,Kuang JY,Liu J,Ma CL,Feng YL,Su ZG

更新日期：2012-08-01 00:00:00